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No prescription prilosec is a proton pump inhibitor (PPI) used to treat ulcers, heartburn, gastroesophageal reflux, or Zollinger-Ellison syndrome. Generic Prilosec What drug(s) may interact with omeprazole? ampicillin diazepam digoxin doxercalciferol iron salts itraconazole, ketoconazole, voriconazole or other prescription medicines for fungus or yeast infections phenytoin warfarin What is the shelf life of the pills? Drug Store. The expiry date is mentioned on each blister. It is different for different batches. The shelf life is 2 years from the date of manufacture and would differ from batch to batch depending on when they were manufactured.